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Partner 1 – German Diabetes Center, Jürgen Eckel

Website: http://www.ddz.uni-duesseldorf.de/index.html

Eckardt K, Sell H, Taube A, Koenen M, Platzbecker B, Cramer A, Horrighs A, Lehtonen M, Tennagels N, Eckel J. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. Diabetologia 52: 664-674, 2009.

Sell H, Eckel J. Chemotactic cytokines, obesity and type 2 diabetes: in vivo and in vitro evidence for a possible causal correlation. Proc Nutr Soc 68: 378-384, 2009.

Taube A, Eckardt K, Eckel J. Role of lipid-derived mediators in skeletal muscle insulin resistance. Am J Physiol 2009, in press

Eckardt K, Sell H, Eckel J. Novel aspects of adipocyte-induced skeletal muscle insulin resistance. Arch Physiol Biochem 114: 287-298, 2008.

Sell H, Eckardt K, Taube A, Tews D, Gurgui M, van Echten-Deckert G, Eckel J. Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility. Am J Physiol Endocrinol Metab: 294, E1070-1077, 2008.

Sell H, Eckel J. Expanded adipose tissue: 'out of breath' and inflamed.Br J Nutr 3: 1-2, 2008.

Swifka J, Weiß J, Addicks K, Eckel J, Rösen P. Epicardial Fat from Guinea Pig: A Model to Study the Paracrine Network of Interactions between Epicardial Fat and Myocardium? Cardiovasc Drugs Ther: 22, 107-114, 2008.

Partner 2 – Karolinska Institutet, Peter Arner

Website: http://ki.se/ki/jsp/polopoly.jsp?l=en&d=8953<//a>

Arner E, Rydén M, Arner P. Tumor necrosis factor alpha and regulation of adipose tissue. N Engl J Med 362: 1151-1153, 2010.

Arner E, Westermark PO, Spalding KL, Britton T, Rydén M, Frisén J, Bernard S, Arner P. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59: 105-109, 2010.

Mejhert N, Laurencikiene J, Pettersson AT, Kaaman M, Stenson BM, Rydén M, Dahlman I. Role of Receptor-Interacting Protein 140 in human fat cells. BMC Endocr Disord 10: 1, 2010.

Pettersson AT, Laurencikiene J, Mejhert N, Näslund E, Bouloumié A, Dahlman I, Arner P, Rydén M. A possible inflammatory role of twist1 in human white adipocytes. Diabetes 59: 564-571, 2010.

Eriksson AK, van Harmelen V, Stenson BM, Astrom G, Wahlen K, Laurencikiene J, Ryden M. Endothelin-1 stimulates human adipocyte lipolysis through the ET A receptor. Int J Obes 33: 67-74, 2009.

Stenson BM, Ryden M, Steffensen KR, Wahlen K, Pettersson AT, Jocken JW, Arner P, Laurencikiene J. Activation of liver X receptor (LXR) regulates substrate oxidation in white adipocytes. Endocrinology 150: 4104-4113, 2009.

Lang P, van Harmelen V, Ryden M, Kaaman M, Parini P, Carneheim C, Cassady AI, Hume DA, Andersson G, Arner P. Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS ONE 3: e1713, 2008.

Laurencikiene J, Stenson BM, Arvidsson Nordstrom E, Agustsson T, Langin D, Isaksson B, Permert J, Ryden M, Arner P. Evidence for an important role of CIDEA in human cancer cachexia. Cancer Res 68: 9247-9254, 2008.

van Harmelen V, Eriksson A, Aström G, Wåhlén K, Näslund E, Karpe F, Frayn K, Olsson T, Andersson J, Rydén M, Arner P. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes 57: 378-386, 2008.

Partner 3 – Institut National de la Santé et de la Recherche Médicale (INSERM), Dominique Langin

Website: http://i2mr.toulouse.inserm.fr/

Bezaire V, Mairal A, Ribet C, Lefort C, Girousse A, Jocken J, Laurencikiene J, Anesia R, Rodriguez AM, Ryden M, Stenson BM, Dani C, Ailhaud G, Arner P, Langin D. Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in Human hMADS Adipocytes. J Biol Chem 284: 18282-18291, 2009.

Capel F, Klimčáková E, Viguerie N, Roussel B, Vítková M, Kováčiková M, Polák J, Kováčová Z, Galitzky J, Maoret JJ, Hanáček J, Pers TH, Bouloumié A, Štich V, Langin D. Macrophages and Adipocytes in Human Obesity: Adipose Tissue Gene Expression and Insulin Sensitivity during Calorie Restriction and Weight Stabilization. Diabetes 58: 1558-1567, 2009.

Kovacova Z et al. Secretion of adiponectin multimeric complexes from adipose tissue explants is not modified by very low calorie diet. Eur J Endocrinol 160: 585-592, 2009.

Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J, Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D. Plasma levels and adipose tissue mRNA expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab 92: 2330-2335, 2007.

Moro C, Klimcakova E, Lolmede K, Berlan M, Lafontan M, Stich V, Bouloumie A, Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia 50: 1038-1047, 2007.

Klimcakova E, Moro C, Mazzucotelli A, Lolmede K, Viguerie N, Galitzky J, Stich V, Langin D. Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists. Biochem Biophys Res Commun 358: 897-902, 2007.

Partner 4 – Stockholm University, Barbara Cannon

Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9: 203-209, 2009.

Walden TB, Timmons JA, Keller P, Nedergaard J, Cannon B. Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes. J Cell Physiol 218: 444-449, 2009.

Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, Feldmann HM, Liang Z, Zhu Z, Nedergaard J, Cannon B, Cao Y. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab 9: 99-109, 2009.

Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 2009, in press

Shabalina IG, Backlund EC, Bar-Tana J, Cannon B, Nedergaard J. Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism. Biochim Biophys Acta 1777: 642-650, 2008.

Partner 5 - Université Pierre et Marie Curie - PARIS 6, Karine Clément

Website: http://www.crc.jussieu.fr/

Website: http://www.obesite-paris.com/

Clément K, Basdevant A, Dutour A. Weight of pericardial fat on coronaropathy. Arterioscler Thromb Vasc Biol 29: 615-616, 2009.

Clément K, Vignes S. Inflammation, adipokines and obesity. Rev Med Interne 2009, in press

Keophiphath M, Achard V, Henegar C, Rouault C, Clément K, Lacasa D. Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes Molecular Endocrinology 23:11-24, 2009.

Mutch DM, Rouault C, Keophiphath M, Lacasa D, Clément K. Using gene expression to predict the secretome of differentiating human preadipocytes. Int J Obes 33: 354-36, 2009.

Mutch DM, Tordjman J, Pelloux V, Hanczar B, Henegar C, Poitou C, Veyrie N, Zucker JD, Clément K. Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles. Am J Clin Nutr 89: 51-57, 2009.

Naour N, Fellahi S, Renucci JF, Poitou C, Rouault C, Basdevant A, Dutour A, Alessi MC, Bastard JP, Clément K, Guerre-Millo M. Potential Contribution of Adipose Tissue to Elevated Serum Cystatin C in Human Obesity. Obesity (Silver Spring) 17: 2121-2126, 2009.

Poitou C, Divoux A, Faty A, Tordjman J, Hugol D, Aissat A, Keophiphath M, Henegar C, Commans S, Clément K. Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux. J Clin Endocrinol Metab 94: 1810-1817, 2009.

Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M, Poitou C, Basdevant A, Stich V, Viguerie N, Langin D, Bedossa P, Zucker JD, Clement K. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol 9: R14, 2008.

Lacasa D, Taleb S, Keophiphath M, Miranville A, Clement K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148: 868-877, 2007.

Partner 6 – Charles University Prague, Vladimir Stich

http://www.lf3.cuni.cz/ 

Kovacikova M, Vitkova M, Klimcakova E, Polak J, Hejnova J, Bajzova M, Kovacova Z, Viguerie N, Langin D, Stich V.  Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction. Eur J Clin Invest 38: 516-522, 2008.

Castan-Laurell I, Vítkova M, Daviaud D, Dray C, Kováciková M, Kovacova Z, Hejnova J, Stich V, Valet P. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur J Endocrinol 158: 905-910, 2008.

Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, Patel K, Oppert JM, Langin D, Martinez JA, Sørensen TI, Stich V. Total adiponectin and adiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study. Eur J Endocrinol 158: 533-541, 2008.

Bajzová M, Kovaciková M, Vitková M, Klimcaková E, Polak J, Kovacová Z, Viguerie N, Vedral T, Mikulášek L, Sramková P, Srp A, Hejnová J, Langin D, Stich V. Retinol -binding protein 4 expression in visceral and subcutaneous fat in human obesity. Physiol Res, epub, 2007.