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Partner 1 – German Diabetes Center, Jürgen Eckel

Website: http://www.ddz.uni-duesseldorf.de/index.html

Famulla S, Lamers D, Hartwig S, Passlack W, Horrighs A, Cramer A, Lehr S, Sell H, Eckel J. Pigment epithelium-derived factor is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells. Int J Obes (Lond), in press, 2011.

Greulich S, De Wiza DH, Preilowksi S, Ding Z, Mueller H, Langin D, Jaquet K, Ouwens DM, Eckel J. Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function. J Cell Mol Med, in press, 2011.

Lamers D, Schlich R, Greulich S, Sasson S, Sell H, Eckel J. Oleic acid and adipokines synergize in inducing proliferation and inflammatory signaling in human vascular smooth muscle cells. J Cell Mol Med, in press, 2011.

Trayhurn P, Drevon CA, Eckel J. Secreted proteins from adipose tissue and skeletal muscle - adipokines, myokines and adipose/muscle cross-talk. Arch Physiol Biochem 2011, in press.

Ouwens DM, Sell H, Greulich S, Eckel J. The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease. J Cell Mol Med 14: 2223-2234, 2010.

Sell H, Divoux A, Poitou C, Basdevant A, Bouillot JL, Bedossa P, Tordjman J, Eckel J, Clément K. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J Clin Endocrinol Metab 95: 2892-2896, 2010.

Eckardt K, Sell H, Taube A, Koenen M, Platzbecker B, Cramer A, Horrighs A, Lehtonen M, Tennagels N, Eckel J. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. Diabetologia 52: 664-674, 2009.

Sell H, Laurencikiene J, Taube A, Eckardt, K, Cramer, A, Horrighs A, Arner P, Eckel, J. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 58: 2731-2740, 2009.

Sell H, Eckel J. Chemotactic cytokines, obesity and type 2 diabetes: in vivo and in vitro evidence for a possible causal correlation. Proc Nutr Soc 68: 378-384, 2009.

Taube A, Eckardt K, Eckel J. Role of lipid-derived mediators in skeletal muscle insulin resistance. Am J Physiol Endocrinol Metab 297: E1004 - E1012, 2009.

Eckardt K, Sell H, Eckel J. Novel aspects of adipocyte-induced skeletal muscle insulin resistance. Arch Physiol Biochem 114: 287-298, 2008.

Sell H, Eckel J. Expanded adipose tissue: 'out of breath' and inflamed.Br J Nutr 3: 1-2, 2008.

Sell H, Eckardt K, Taube A, Tews D, Gurgui M, van Echten-Deckert G, Eckel J. Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility. Am J Physiol Endocrinol Metab: 294, E1070-1077, 2008.

Swifka J, Weiß J, Addicks K, Eckel J, Rösen P. Epicardial Fat from Guinea Pig: A Model to Study the Paracrine Network of Interactions between Epicardial Fat and Myocardium? Cardiovasc Drugs Ther: 22, 107-114, 2008.

Partner 2 – Karolinska Institutet, Peter Arner

Website: http://ki.se/ki/jsp/polopoly.jsp?l=en&d=8953<//a>

Arner E, Rydén M, Arner P. Tumor necrosis factor alpha and regulation of adipose tissue. N Engl J Med 362: 1151-1153, 2010.

Arner E, Westermark PO, Spalding KL, Britton T, Rydén M, Frisén J, Bernard S, Arner P. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59: 105-109, 2010.

Mejhert N, Laurencikiene J, Pettersson AT, Kaaman M, Stenson BM, Rydén M, Dahlman I. Role of Receptor-Interacting Protein 140 in human fat cells. BMC Endocr Disord 10: 1, 2010.

Pettersson AT, Laurencikiene J, Mejhert N, Näslund E, Bouloumié A, Dahlman I, Arner P, Rydén M. A possible inflammatory role of twist1 in human white adipocytes. Diabetes 59: 564-571, 2010.

Eriksson AK, van Harmelen V, Stenson BM, Astrom G, Wahlen K, Laurencikiene J, Ryden M. Endothelin-1 stimulates human adipocyte lipolysis through the ET A receptor. Int J Obes 33: 67-74, 2009.

Stenson BM, Ryden M, Steffensen KR, Wahlen K, Pettersson AT, Jocken JW, Arner P, Laurencikiene J. Activation of liver X receptor (LXR) regulates substrate oxidation in white adipocytes. Endocrinology 150: 4104-4113, 2009.

Lang P, van Harmelen V, Ryden M, Kaaman M, Parini P, Carneheim C, Cassady AI, Hume DA, Andersson G, Arner P. Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity. PLoS ONE 3: e1713, 2008.

Laurencikiene J, Stenson BM, Arvidsson Nordstrom E, Agustsson T, Langin D, Isaksson B, Permert J, Ryden M, Arner P. Evidence for an important role of CIDEA in human cancer cachexia. Cancer Res 68: 9247-9254, 2008.

van Harmelen V, Eriksson A, Aström G, Wåhlén K, Näslund E, Karpe F, Frayn K, Olsson T, Andersson J, Rydén M, Arner P. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes 57: 378-386, 2008.

Partner 3 – Institut National de la Santé et de la Recherche Médicale (INSERM), Dominique Langin

Website: http://i2mr.toulouse.inserm.fr/

Langin D. Recruitment of brown fat and conversion of white into brown adipocytes: strategies to fight the metabolic complications of obesity? Biochim Biophys Acta 1801: 372-376, 2010.

Klimcakova E, Kovacikova M, Stich V, Langin D. Adipokines and dietary interventions in human obesity. Obes Rev 11: 446-456, 2010.

Bezaire V, Langin D. Regulation of adipose tissue lipolysis revisited. Proc Nutr Soc 68: 350-360, 2009.

Bezaire V, Mairal A, Ribet C, Lefort C, Girousse A, Jocken J, Laurencikiene J, Anesia R, Rodriguez AM, Ryden M, Stenson BM, Dani C, Ailhaud G, Arner P, Langin D. Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes. J Biol Chem 284: 18282-18291, 2009.

Capel F, Klimčáková E, Viguerie N, Roussel B, Vítková M, Kováčiková M, Polák J, Kováčová Z, Galitzky J, Maoret JJ, Hanáček J, Pers TH, Bouloumié A, Štich V, Langin D. Macrophages and Adipocytes in Human Obesity: Adipose Tissue Gene Expression and Insulin Sensitivity during Calorie Restriction and Weight Stabilization. Diabetes 58: 1558-1567, 2009.

Kovacova Z et al. Secretion of adiponectin multimeric complexes from adipose tissue explants is not modified by very low calorie diet. Eur J Endocrinol 160: 585-592, 2009.

Moro C, Klimcakova E, Lolmede K, Berlan M, Lafontan M, Stich V, Bouloumie A, Galitzky J, Arner P, Langin D. Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia 50: 1038-1047, 2007.

Klimcakova E, Moro C, Mazzucotelli A, Lolmede K, Viguerie N, Galitzky J, Stich V, Langin D. Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists. Biochem Biophys Res Commun 358: 897-902, 2007.

Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J, Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D. Plasma levels and adipose tissue mRNA expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab 92: 2330-2335, 2007.

Partner 4 – Stockholm University, Barbara Cannon

Cannon B, Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes 34, Suppl. 1: S7-S16, 2010.

Dahlman I, Mejhert N, Linder K, Agustsson T, Mutc DM, Kulyte A, Isaksson B, Permert J, Petrovic N, Nedergaard J, Sjölin E, Brodin D, Clement K, Dahlman-Wright K, Rydén M, Arner P. Adipose tissue pathways involved in weight loss of cancer cachexia. Brit J Cancer 102: 1541-1548, 2010.

Holmström T, Mattsson CL, Wang Y, Iakovleva I, Petrovic N, Nedergaard J. Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes. Exp. Cell Res 316: 2664-2675, 2010.

Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J. Chronic PPARgamma activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classical brown adipocytes. J Biol Chem 285: 7153-7164, 2010.

Shabalina IG, Ost M, Petrovic N, Vrbacky M, Nedergaard J, Cannon B. Uncoupling protein-1 is not leaky. Biochim Biophys Acta - Bioenergetics 1797: 773-784, 2010.

Shabalina IG, Hoeks J, Kramarova TV, Schrauwen P, Cannon B, Nedergaard J. Cold tolerance of UCP1-ablated mice: A skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects. Biochim Biophys Acta - Bioenergetics 1797: 968-980, 2010.

Waldén T, Petrovic N, Nedergaard J. PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte. Biochem. Biophys. Res. Commun 397: 146-151, 2010.

Cannon B, Nedergaard J. Thermogenesis challenges the adipostat hypothesis for body-weight control. Proc Nutr Soc 68: 401-407, 2009.

Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metabolism 9(2): 203-209, 2009.

Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, Feldmann HM, Liang Z, Zhu Z, Nedergaard J, Cannon B, Cao Y. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab 9: 99-109, 2009.

Walden TB, Timmons JA, Keller P, Nedergaard J, Cannon B. Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes. J Cell Physiol 218: 444-449, 2009.

Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 23: 3113-3120, 2009.

Shabalina IG, Backlund EC, Bar-Tana J, Cannon B, Nedergaard J. Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism. Biochim Biophys Acta 1777: 642-650, 2008.

Partner 5 - Université Pierre et Marie Curie - PARIS 6, Karine Clément

Website: http://www.crc.jussieu.fr/

Website: http://www.obesite-paris.com/

Capuron L, Poitou C, Machaux-Tholliez D, Frochot V, Bouillot JL, Basdevant A, Layé S, Clément K. Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med, in press, 2011.

Dalmas E, Clément K, Guerre-Millo M. Defining marcophage phenotype and function in adipose tissue. Trends Immunol, in press, 2011.

Richette P, Poitou C, Garnero P, Vicaut E, Bouillot JL, Lacorte JM, Basdevant A, Clément K, Bardin T, Chevalier X. Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis. Ann Rheum Dis 70: 139-144, 2011.

Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, Basdevant A, Guerre-Millo M, Poitou C, Zucker JD, Bedossa P, Clément K. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 59: 2817-2825, 2010.

Dutour A, Achard V, Sell H, Naour N, Collart F, Gaborit B, Silaghi A, Eckel J, Alessi MC, Henegar C, Clément K. Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with coronary artery disease. J Clin Endocrinol Metab 95: 963-967, 2010.

Keophiphath M, Rouault C, Divoux A, Clément K, Lacasa D. CCL5 promotes macrophage recruitment and survival in human adipose tissue, Arterioscler Thromb Vasc Biol 30: 39-45, 2010.

Naour N, Rouault C, Fellahi S, Lavoie ME, Poitou C, Keophiphath M, Eberlé D, Shoelson S, Rizkalla S, Bastard JP, Rabasa-Lhoret R, Clément K, Guerre-Millo M. Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin S in adipose tissue and in circulation. J Clin Endocrinol Metab 95: 1861-1868, 2010.

Villaret A, Galitzky J, Decaunes P, Estève D, Marques MA, Sengenès C, Chiotasso P, Tchkonia T, Lafontan M, Kirkland JL, Bouloumié A. Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence. Diabetes 59: 2755-2763, 2010.

Zaragosi LE,Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, Dani C. Actin Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors. Diabetes 59: 2513-2521, 2010.

Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D, Basdevant A, Aissat A, Guerre-Millo M and Clément K. Human adipose tissue macrophages: M1 and M2 cell surface markers in subcutaneous and omental depots and after weight loss. J Clin Endocrinol Metab 94: 4619-4623, 2009.

Clément K, Vignes S. Inflammation, adipokines and obesity. Rev Med Interne 30: 824-832, 2009.

Clément K, Basdevant A, Dutour A. Weight of pericardial fat on coronaropathy. Arterioscler Thromb Vasc Biol 29: 615-616, 2009.

Duffaut C, Zakaroff-Girard A, Bourlier V, Decaunes P, Maumus M, Chiotasso P, Sengenès C, Lafontan M, Galitzky J, Bouloumié A. Interplay Between Human Adipocytes and T Lymphocytes in Obesity. CCL20 as an Adipochemokine and T Lymphocytes as Lipogenic Modulators. Arterioscler Thromb Vasc Biol 29: 1608-1614, 2009.

Duffaut C, Galitzky J, Lafontan M, Bouloumié A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun 384: 482-485, 2009.

Keophiphath M, Achard V, Henegar C, Rouault C, Clément K, Lacasa D. Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes. Mol Endocrinol 23: 11-24, 2009.

Mutch DM, Tordjman J, Pelloux V, Hanczar B, Henegar C, Poitou C, Veyrie N, Zucker JD, Clément K. Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles. Am J Clin Nutr 89: 51-57, 2009.

Mutch DM, Rouault C, Keophiphath M, Lacasa D, Clément K. Using gene expression to predict the secretome of differentiating human preadipocytes. Int J Obes 33: 354-36, 2009.

Naour N, Fellahi S, Renucci JF, Poitou C, Rouault C, Basdevant A, Dutour A, Alessi MC, Bastard JP, Clément K, Guerre-Millo M. Potential Contribution of Adipose Tissue to Elevated Serum Cystatin C in Human Obesity. Obesity (Silver Spring) 17: 2121-2126, 2009.

Poitou C, Divoux A, Faty A, Tordjman J, Hugol D, Aissat A, Keophiphath M, Henegar C, Commans S, Clément K. Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux. J Clin Endocrinol Metab 94: 1810-1817, 2009.

Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M, Poitou C, Basdevant A, Stich V, Viguerie N, Langin D, Bedossa P, Zucker JD, Clement K. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol 9: R14, 2008.

Lacasa D, Taleb S, Keophiphath M, Miranville A, Clement K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148: 868-877, 2007.

Partner 6 – Charles University Prague, Vladimir Stich

http://www.lf3.cuni.cz/ 

Hněvkovská Z, Dietrich J, Siklová-Vítková M, Kološtová K, Kováčiková M, Dušková M, Brož J, Vedral T, Stich V, Polák J. Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms. Physiol. Res, in press, 2011.

Klimcakova E, Roussel B, Kovacova Z, Kovacikova M, Siklova-Vitkova M, Combes M, Hejnova J, Decaunes P, Maoret JJ, Vedral T. Macrophage gene expression is related to obesity and metabolic syndrome in human subcutaneous fat as well as in visceral fat. Diabetologia, in press, 2011.

Siklova-Vitkova M, Polak J, Klimcakova E, Vrzalova J, Hejnova J, Kovacikova M, Kovacova Z, Bajzova M, Rossmeislova L, Hnevkovska Z, Langin D, Stich V . Effect of hyperinsulinemia and very-low-calorie diet on interstitial cytokine levels in subcutaneous adipose tissue of obese women. Am J Physiol Endocrinol Metab 297: E1154-E1161, 2009.

Bajzová M, Kovaciková M, Vitková M, Klimcaková E, Polak J, Kovacová Z, Viguerie N, Vedral T, Mikulášek L, Sramková P, Srp A, Hejnová J, Langin D, Stich V. Retinol -binding protein 4 expression in visceral and subcutaneous fat in human obesity. Physiol Res 57: 927-934, 2008.

Castan-Laurell I, Vítkova M, Daviaud D, Dray C, Kováciková M, Kovacova Z, Hejnova J, Stich V, Valet P. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur J Endocrinol 158: 905-910, 2008.

Kovacikova M, Vitkova M, Klimcakova E, Polak J, Hejnova J, Bajzova M, Kovacova Z, Viguerie N, Langin D, Stich V. Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction. Eur J Clin Invest 38: 516-522, 2008.

Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, Patel K, Oppert JM, Langin D, Martinez JA, Sørensen TI, Stich V. Total adiponectin and adiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study. Eur J Endocrinol 158: 533-541, 2008.